PACE-KD outcomes, measurement methods and assessment time periods
| Outcome | Measurement method/tool | Time period |
| Feasibility | Recruitment, compliance, dropout and completion percentages | Continuous |
| VO2 peak | CPET | Baseline, post-training |
| Physical function | Gait speed test | Baseline, midtraining, post-training, three months post-training |
| Sit to stand test | ||
| Plantar flexion strength (Fysiometer) | ||
| Body composition | BIA | Baseline, midtraining, post-training, three months post-training |
| Heart function | NICOM | Baseline, midtraining, post-training, three months post-training |
| Arterial stiffness | PWV (applanation tonometry) | Baseline, midtraining, post-training, three months post-training |
| SpO2 | Pulse oximetry | Baseline, midtraining, post-training, three months post-training, acute response sessions |
| Habitual physical activity | Accelerometry | Baseline, post-training |
| Muscle O2saturation | NIRS | Acute response session |
| Urinary bacteriuria | Urine sample | Baseline, midtraining, post-training |
| Immune function | Blood and saliva samples | Baseline, midtraining, post-training, three months post-training, acute response sessions |
| Markers of inflammation, oxidative stress, CVD risk | Blood samples | Baseline, midtraining, post-training, three months post-training, acute response sessions |
| Renal profile | Blood samples | Baseline, post-training |
| Clinical information | Extraction from clinical notes | Baseline, midtraining, post-training, three months post-training |
| Renal symptoms | POS-S | Baseline, midtraining, post-training, three months post-training |
| Fatigue | Fatigue scale | Baseline, midtraining, post-training, three months post-training |
| Quality of life | EQ-5D | Baseline, midtraining, post-training, three months post-training |
| Illness perception | IPQ-R | Baseline, midtraining, post-training, three months post-training |
| Physical activity/functional capacity | DASI | Baseline, midtraining, post-training, three months post-training |
| Pain | BPI | Baseline, midtraining, post-training, three months post-training |
| Sleep quality | PSQI | Baseline, midtraining, post-training, three months post-training |
| Daytime sleepiness | ESS | Baseline, midtraining, post-training, three months post-training |
| Illness symptoms | PACE-KD Illness-Symptom Questionnaire | Before each exercise session and ×1 at the weekend between sessions |
| Tolerability, practicality, acceptability and perceived usefulness of the study measures | PSQ; Semi-structured interview or focus group | Post-study involvement; Post-study involvement through optional QPACE-KD nested qualitative study |
BIA, Bioelectrical Impedance Analysis; BPI, Brief Pain Inventory; CPET, Cardiopulmonary Exercise Test; CVD, Cardiovascular Disease; DASI, Duke Activity Status Index; EQ-5D, EuroQol 5 Dimension; ESS, Epworth Sleepiness Scale; IPQ-R, Illness Perception Questionnaire—Revised; NICOM, Non-Invasive Cardiac Output Monitor; NIRS, Near-Infrared Spectroscopy; POS-S, Renal Patient Outcome Scale; PSQ, Patient Satisfaction Questionnaire; PSQI, Pittsburgh Sleep Quality Index; SpO2, Peripheral Oxygen Saturation; VO2peak, peak oxygen uptake.