Table 2

Inclusion and exclusion criteria

Inclusion criteriaExclusion criteria
Healthy volunteersWritten informed consent
No contra-indication to MRI
40 years or above in age (attempts will be made to include similar age range as myeloma patients)
No known significant illness
No known metallic implant		Significant artefact on scan
Corrupted scan data
Patients in phases 1 and 2Patient with confirmed myeloma with WB-MRI scan previously performed as part of clinical care.
Sufficient imaging and clinical data for the expert reference panel to categorise the WB-MRI scan as:

  1. Previously treated inactive disease with no evidence of active disease based on expert reference panel

  2. Active disease—focal

  3. Active disease—diffuse

  4. Active disease—extra-medullary

  5. New active myeloma, no previous treatment


Patients may be included if the pattern of disease is a combination of focal, diffuse and/or extra-medullary.		Corrupted WB-MRI scan data.
Insufficient clinical data to allow the expert reference panel to categorise the scan.
Patients in phase 3Training set: phase 1 active disease cases and their post-treatment scans from phase 2.
Validation set: from iTIMM study.
Written informed consent for iTIMM study
All patients over the age of 18 with multiple myeloma planned for autograft.		Corrupted scan data.
MRI incompatible metal implants
Claustrophobia
Diagnosis of other malignancy within 5 years

  • iTIMM, Image-guided Theranostics in Multiple Myeloma; WB-MRI, Whole-Body Magnetic Resonance Imaging.