Table 1

Inclusion and exclusion criteria

Inclusion criteriaExclusion criteria
For trio whole-genome sequencing
 New diagnosis of malignancy
 Patient age ≤21 years
 Written informed consent
Psychosocial component: biological parents
Give written informed consent
Speak/read conversational EnglishSevere depression and/or suicidality*
Able to provide details of a trusted health professionalCurrent psychotic episode*
Significant substance abuse*
Psychosocial component: patients
Age ≥12 years
Speak/read conversational EnglishDeemed too unwell by parent or doctor
Current psychotic episode*
Other significant difficulties which impact the ability to complete questionnaires

  • *Identified through contact with the patient’s treating clinician or screening by the study psychologist.