Table 3

Minimum detectable OR with a cleft subtype case sample and non-cleft control sample, 80% power and probability of a type 1 error at 5%

Case-to-control* ratio
1:11:21:31:4
Cleft lip only (n=1157)
Proportion of control sample* exposed0.11.441.391.371.33
0.21.321.291.271.25
0.31.281.261.241.22
0.41.271.241.231.21
Cleft palate only (n=2112)
0.11.311.281.271.24
0.21.231.211.201.18
0.31.201.181.171.16
0.41.191.171.161.15
Unilateral cleft lip and palate (n=1042)
0.11.461.421.391.35
0.21.341.311.291.26
0.31.301.271.251.23
0.41.281.251.241.22
Bilateral cleft lip and palate (n=511)
0.11.701.621.581.52
0.21.511.461.431.39
0.31.451.401.381.34
0.41.421.381.361.32
  • *Control sample would need to be obtained from an additional source.