Minimum detectable OR with a cleft subtype case sample and non-cleft control sample, 80% power and probability of a type 1 error at 5%
Case-to-control* ratio | |||||
1:1 | 1:2 | 1:3 | 1:4 | ||
Cleft lip only (n=1157) | |||||
Proportion of control sample* exposed | 0.1 | 1.44 | 1.39 | 1.37 | 1.33 |
0.2 | 1.32 | 1.29 | 1.27 | 1.25 | |
0.3 | 1.28 | 1.26 | 1.24 | 1.22 | |
0.4 | 1.27 | 1.24 | 1.23 | 1.21 | |
Cleft palate only (n=2112) | |||||
0.1 | 1.31 | 1.28 | 1.27 | 1.24 | |
0.2 | 1.23 | 1.21 | 1.20 | 1.18 | |
0.3 | 1.20 | 1.18 | 1.17 | 1.16 | |
0.4 | 1.19 | 1.17 | 1.16 | 1.15 | |
Unilateral cleft lip and palate (n=1042) | |||||
0.1 | 1.46 | 1.42 | 1.39 | 1.35 | |
0.2 | 1.34 | 1.31 | 1.29 | 1.26 | |
0.3 | 1.30 | 1.27 | 1.25 | 1.23 | |
0.4 | 1.28 | 1.25 | 1.24 | 1.22 | |
Bilateral cleft lip and palate (n=511) | |||||
0.1 | 1.70 | 1.62 | 1.58 | 1.52 | |
0.2 | 1.51 | 1.46 | 1.43 | 1.39 | |
0.3 | 1.45 | 1.40 | 1.38 | 1.34 | |
0.4 | 1.42 | 1.38 | 1.36 | 1.32 |
*Control sample would need to be obtained from an additional source.