Operating characteristics of the continuous reassessment model
| Starting dose level 1, dose-skipping not allowed, 3 dose levels, maximum 24 participants. Skeleton (a priori probabilities of DLE) = 0.05, 0.11, 0.20 target DLE rate=no greater than 20% | |||
| Dose level | |||
| 1 | 2 | 3 | |
| Scenario 1: recommendation (%) | 2.5 | 24.5 | 73.0 |
| Scenario 2: recommendation (%) | 22.5 | 46.5 | 31.0 |
| Scenario 3: recommendation (%) | 0.0 | 3.3 | 96.7 |
| Scenario 1: true probabilities=a priori probabilities Scenario 2: true probabilities=0.10, 0.20, 0.30 Scenario 3: true probabilities=0.02, 0.05, 0.10 | |||
DLE, dose-limiting event.