Participant baseline characteristics by randomised treatment
| Placebo | Triple Pill | Overall | Overall | |
| Mean (SD) | Mean (SD) | Mean (SD) | Median (range) | |
| Number of participants | 4 | 2 | 6 | 6 |
| Female | 2 | 1 | 3 | 3 |
| Age, years | 62.7 (6.4) | 63.5 (9.9) | 63.0 (6.7) | 61.7 (56.5, 70.5) |
| Height, cm | 166.5 (10.0) | 165.0 (9.9) | 166.0 (8.9) | 168.5 (153.0, 175.0) |
| Weight, kg | 89.5 (13.2) | 66.5 (6.4) | 81.8 (15.9) | 80.5 (62.0, 105.0) |
| BMI | 32.5 (5.5) | 24.4 (0.6) | 29.8 (6.0) | 28.11 (24.0, 39.3) |
| Smoking | ||||
| Never smoker | 2 | 1 | 3 | 3 |
| Ex-smoker | 2 | 1 | 3 | 3 |
| Alcohol, >1 per week | 2 | 2 | 4 | 4 |
| Highest level of education | ||||
| Undergraduate degree | 1 | 1 | 2 | 2 |
| Postgraduate degree | 2 | 1 | 3 | 3 |
| Other | 1 | 1 | 1 | |
| Systolic BP | 128.8 (7.4) | 138.9 (1.6) | 132.2 (7.8) | 133.3 (121.7, 140.1) |
| Diastolic BP | 83.1 (2.1) | 87.9 (4.1) | 84.7 (3.5) | 84.4 (80.0, 90.8) |
| Heart rate | 72.6 (3.2) | 68.2 (NA) | 71.7 (3.4) | 72.7 (68.2, 76.2) |
| Glucose, mmol/L | 5.3 (0.45) | 5.0 (0.28) | 5.2 (0.40) | 5.2 (4.7, 5.7) |
| Total cholesterol, mmol/L | 4.7 (1.04) | 5.6 (0.57) | 5.0 (0.97) | 5.2 (3.2, 6.0) |
| LDL, mmol/L | 2.75 (0.91) | 2.90 (0.14) | 2.8 (0.71) | 2.9 (1.5, 3.6) |
| HDL, mmol/L | 1.23 (0.34) | 2.25 (0.35) | 1.57 (0.61) | 1.45 (0.90, 2.50) |
| Triglycerides, mmol/L | 1.55 (0.40) | 0.95 (0.21) | 1.35 (0.45) | 1.30 (0.80, 1.90) |
| Creatinine, µmmol/L | 87.5 (22.5) | 80.0 (14.1) | 85.0 (19.0) | 90.0 (55.0, 105.0) |
| Sodium, mmol/L | 139.0 (2.9) | 138.5 (2.1) | 138.8 (2.5) | 139.5 (135.0, 142.0) |
| Potassium, mmol/L | 4.35 (0.39) | 4.40 (0) | 4.37 (0.30) | 4.35 (4.00, 4.90) |
| BUN /urea, mmol/L | 5.05 (1.41) | 6.00 (0.99) | 5.37 (1.27) | 5.7 (3.6, 6.7) |
| eGRF, mL/min/1.73m2 | 70.3 (13.3) | 81.5 (3.5) | 74 (11.9) | 72 (61, 90) |
| AST, IU/I | 21.8 (5.5) | 35.0 (1.4) | 26.2 (8.1) | 26 (17, 36) |
| ALT, IU/l | 30.8 (14.8) | 21 (0) | 27.5 (12.5) | 21.5 (16, 49) |
ALT, alanine transaminase; AST, aspartate aminotransferase; BMI, body mass index; BP, blood pressure; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein.