| 1. Basic study characteristics | Title Author Year of publication Publication date (including dates of other systematic reviews yearly ranges) Country Study settings Study design (RCTs, conference abstracts, non-RCTs, cluster RCTs, quasi experimental studies (specific study design)) Interventions performed Study period (MMYYYY to MMYYYY)
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| 2. Population of interest | Heterosexual serodiscordant couples MSM (men who have sex with men) serodiscordant couples WSW (women who have sex with women) serodiscordant couples Monogamous, non-monogamous, casual, short term, committed and open
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| 3. Population demographics | Number of participants (or # of pairs)Sexual orientation/preference Type and frequency of sexual acts Length of follow-up Amount lost to follow-up/retention/drop-out Age
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| 4. Exposure types | ART: dose, timing, duration and adherence HIV: viral load testing (50–>1000 copies/mL or greater), CD4 testing Sexually transmissible infection (STI) screening, frequency and condom use HIV+ partner viral load copies/mL during transmission HIV− partner frequency of HIV testing
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| 5. Comparators (there might not be a comparator) and outcomes | Risk of HIV transmission in serodiscordant couples with PLHIV (persons living with HIV) on ART and having a viral load varying from 50 to >1000 copies/mL or greater. Absolute HIV transmission, 95% CI viral load copies/mL per person-years Incidence of HIV transmission per type of sexual act (penile–vaginal, oral and anal receptive and insertive) Incidence of HIV+ partners Person years/months follow-up on ART Time from the initiation of ART to contracting HIV Number of HIV+ partners on ART Phylogenetic linkage during transmission between serodiscordant couples Suppressed viral load (50–1000), undetectable viral load (<50) Viral load of >1000 copies/mL
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