Multivariate models for lung function and both Alu and LINE-1 methylation*
| Alu | LINE-1 | |||
|---|---|---|---|---|
| β | p Value | Β | p Value | |
| FEV1 | 0.028 | 0.017 | −0.015 | 0.08 |
| FVC | 0.027 | 0.06 | −0.017 | 0.11 |
| FEV1/FVC | 0.3 | 0.057 | −0.092 | 0.44 |
| COPD | 0.85 (0.71 to 1.03) | 0.09 | 1.01 (0.89 to 1.15) | 0.83 |
*Adjusted for age, height, race, BMI, pack-years of smoking, smoking status. Models with LINE-1 also include per cent lymphocytes.
BMI, body mass index; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; LINE-1, long-interspersed nuclear elements.