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  • Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (‘CUPID’ study): protocol for a randomised, double-blind, placebo-controlled, cross-over, three-arm, proof-of-concept trial

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Research methods
Protocol
Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (‘CUPID’ study): protocol for a randomised, double-blind, placebo-controlled, cross-over, three-arm, proof-of-concept trial

Authors

  • Isobel Lavender Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, AustraliaLambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, AustraliaFaculty of Science, School of Psychology, The University of Sydney, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Danielle McCartney Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, AustraliaLambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, AustraliaFaculty of Science, School of Psychology, The University of Sydney, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Nathaniel Marshall Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, AustraliaFaculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Anastasia Suraev Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, AustraliaLambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, AustraliaFaculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Chris Irwin School of Health Sciences and Social Work, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia PubMed articlesGoogle scholar articles
  • Angela L D'Rozario Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, AustraliaFaculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Christopher J Gordon Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, AustraliaSusan Wakil School of Nursing and Midwifery, The University of Sydney, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Bandana Saini Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Ronald R Grunstein Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, AustraliaFaculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, New South Wales, AustraliaCPC-RPA clinic, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Brendon Yee Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, AustraliaFaculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, New South Wales, AustraliaCPC-RPA clinic, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Iain McGregor Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, AustraliaFaculty of Science, School of Psychology, The University of Sydney, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Camilla M Hoyos Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, AustraliaFaculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Camilla M Hoyos; camilla.hoyos{at}mq.edu.au
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Citation

Lavender I, McCartney D, Marshall N, et al
Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (‘CUPID’ study): protocol for a randomised, double-blind, placebo-controlled, cross-over, three-arm, proof-of-concept trial
BMJ Open 2023;13:e071148. doi: 10.1136/bmjopen-2022-071148

Publication history

  • Received December 21, 2022
  • Accepted August 7, 2023
  • First published August 23, 2023.
Online issue publication 
February 22, 2024
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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.