Clinical Pharmacology

PCSK9 inhibitors for anti-inflammation in atherosclerosis: protocol for a systematic review and meta-analysis of randomised controlled trials
Jichang Luo, Wanying Liao, Xue Wang, Ran Xu, Wei Li, Wenjing Li, Kan Liu, Kaixun Huang, Yan Ma, Tao Wang, Bin Yang, Liqun Jiao

BMJ Open Nov 2022, 12 (11) e062046; DOI: 10.1136/bmjopen-2022-062046
What is the impact of targeted therapies given within phase I trials on the cognitive function of patients with advanced cancer: a mixed-methods exploratory study conducted in an early clinical trials unit
Sarah Stapleton, Anne-Sophie Emma Darlington, J S de Bono, Theresa Wiseman

BMJ Open Nov 2022, 12 (11) e050590; DOI: 10.1136/bmjopen-2021-050590
Optimisation of treatments for oral Neisseria gonorrhoeae infection: Pharmacokinetics Study (STI-PK project) – study protocol for non-randomised clinical trial
Fabian Y S Kong, Magnus Unemo, Shueh H Lim, Ngaire Latch, Deborah A Williamson, Jason A Roberts, Steven C Wallis, Suzanne L Parker, Cornelia B Landersdorfer, Tami Yap, Christopher K Fairley, Eric P F Chow, David A Lewis, Mohamed A Hammoud, Jane S Hocking

BMJ Open Nov 2022, 12 (11) e064782; DOI: 10.1136/bmjopen-2022-064782
Home-based multidisciplinary interventions on skin adverse reactions in EGFR-TKI-treated patients with lung cancer: a protocol for a randomised controlled trial
Ruofei Du, Huashan Yang, Huiyue Zhou, Lixia Ma, Mikiyas Amare Getu, Changying Chen, Tao Wang

BMJ Open Nov 2022, 12 (11) e063921; DOI: 10.1136/bmjopen-2022-063921
Observational and prospective study: evaluation of beliefs and representations of chronic treatments of polymedicated patients hospitalised in a vascular medicine and surgery department
Dounia Kotry, Justine Saillard, Marion Bonsergent, Christelle Volteau, Antoine Benichou, Sonia Prot-Labarthe, Jean-François Huon

BMJ Open Dec 2023, 13 (12) e073250; DOI: 10.1136/bmjopen-2023-073250
Impact of the SGLT2 inhibitor empagliflozin on urinary supersaturations in kidney stone formers (SWEETSTONE trial): protocol for a randomised, double-blind, placebo-controlled cross-over trial
Simeon Schietzel, Lia Bally, Grazia Cereghetti, Nicolas Faller, Matthias B Moor, Bruno Vogt, Felix Rintelen, S Trelle, Daniel Fuster

BMJ Open Mar 2022, 12 (3) e059073; DOI: 10.1136/bmjopen-2021-059073
Unplanned nursing home admission among discharged polymedicated older inpatients: a single-centre, registry-based study in Switzerland
Filipa Pereira, Henk Verloo, Armin von Gunten, María del Río Carral, Carla Meyer-Massetti, Maria Manuela Martins, Boris Wernli

BMJ Open Mar 2022, 12 (3) e057444; DOI: 10.1136/bmjopen-2021-057444
Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)
David Ekqvist, Anna Bornefall, Daniel Augustinsson, Martina Sönnerbrandt, Michaela Jonsson Nordvall, Mats Fredrikson, Björn Carlsson, Mårten Sandstedt, Ulrika S H Simonsson, Jan-Willem C Alffenaar, Jakob Paues, Katarina Niward

BMJ Open Mar 2022, 12 (3) e054788; DOI: 10.1136/bmjopen-2021-054788
Uptake of the multi-arm multi-stage (MAMS) adaptive platform approach: a trial-registry review of late-phase randomised clinical trials
Nurulamin M Noor, Sharon B Love, Talia Isaacs, Richard Kaplan, Mahesh K B Parmar, Matthew R Sydes

BMJ Open Mar 2022, 12 (3) e055615; DOI: 10.1136/bmjopen-2021-055615
Risk of pneumonia in asthmatic children using inhaled corticosteroids: a nested case-control study in a birth cohort
Pragya Shrestha, Chung-Il Wi, Hongfang Liu, Katherine S King, Euijung Ryu, Jung Hyun Kwon, Sunghwan Sohn, Miguel Park, Young Juhn

BMJ Open Mar 2022, 12 (3) e051926; DOI: 10.1136/bmjopen-2021-051926

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