clinical trials

Trial to assess the tolerability of using felodipine to upregulate autophagy as a treatment of Huntington’s disease (FELL-HD): a phase II, single-centre, open-label, dose-finding trial protocol
Katie Andresen, Emma Cutting, Dimitrios Apostolopoulos, Amy H Evans, Laura Oakley, Alimu Dayimu, Nikolaos Demiris, Katherine Bongaerts, Robyn Staples, Wendy Gooding, David Rubinsztein, Roger A Barker

BMJ Open Aug 2024, 14 (8) e087983; DOI: 10.1136/bmjopen-2024-087983
Treating severe paediatric asthma with mepolizumab or omalizumab: a protocol for the TREAT randomised non-inferiority trial
Victoria Cornelius, Daphne Babalis, William D Carroll, Steven Cunningham, Louise Fleming, Erol Gaillard, Atul Gupta, Leila Janani, Erika Kennington, Clare Murray, Prasad Nagakumar, Graham Roberts, Paul Seddon, Ian Sinha, Claire Streatfield, Elise Weir, Sejal Saglani

BMJ Open Aug 2024, 14 (8) e090749; DOI: 10.1136/bmjopen-2024-090749
Easing the way to achieving target serum urate in people with gout: protocol for a non-inferiority randomised strategy trial using an allopurinol dosing model in Aotearoa/New Zealand (the Easy-Allo Study)
Lisa Stamp, Leanne Te Karu, Susan Reid, Daniel F B Wright, Chris Frampton, Vui Suli Tuitaupe, Nicola Dalbeth

BMJ Open Aug 2024, 14 (8) e084665; DOI: 10.1136/bmjopen-2024-084665
Designing a single-arm phase 2 clinical trial of mitapivat for adult patients with erythrocyte membranopathies (SATISFY): a framework for interventional trials in rare anaemias – pilot study protocol
Andreas Glenthøj, Eduard J van Beers, Richard van Wijk, Minke A E Rab, Evelyn Groot, Niels Vejlstrup, Nina Toft, Selma Kofoed Bendtsen, Jesper Petersen, Jens Helby, Fatiha Chermat, Pierre Fenaux, Kevin H M Kuo

BMJ Open Jul 2024, 14 (7) e083691; DOI: 10.1136/bmjopen-2023-083691
False claims of equivalence in the neurosurgical trauma literature: prevalence and associated factors—a systematic review protocol
André Luiz Freitas Oliveira Júnior, João Vitor Miranda Porto Oliveira, Angelos G Kolias, Wellingson S Paiva, Davi Jorge Fontoura Solla

BMJ Open Jul 2024, 14 (7) e044794; DOI: 10.1136/bmjopen-2020-044794
Feasibility and efficacy of virtual reality rehabilitation compared with conventional physiotherapy for upper extremity impairment due to ischaemic stroke: protocol for a randomised controlled trial
Rinta Paul, Sundari Elango, Srinivasa Chakravarthy, Aniruddha Sinha, Srijithesh P R, Bapi Raju, Kesavadas C, P Sankara Sarma, Shabeera Hafsath, Amal Jude Ashwin Francis, Divya Darshini, Padmavathy Narayanapillai Sylaja

BMJ Open Jul 2024, 14 (7) e086556; DOI: 10.1136/bmjopen-2024-086556
Core socioDemographic data variables in ICU Trials (CoDe-IT): a protocol for generating core data variables using a Delphi consensus process
Karla D Krewulak, Fatima Sheikh, Alya Heirali, John C Marshall, Karen E A Burns, Scotty Kupsch, Christina Maratta, Srinivas Murthy, Katie O'Hearn, Kristine Russell, Sangeeta Mehta, Kirsten Fiest

BMJ Open Jul 2024, 14 (7) e082912; DOI: 10.1136/bmjopen-2023-082912
Switching from Dose-Intensified intravenous to SubCutaneoUS infliximab in Inflammatory Bowel Disease (DISCUS-IBD): protocol for a multicentre randomised controlled trial
Robert D Little, Jo McKenzie, Ashish Srinivasan, Patrick Hilley, Robert B Gilmore, Desmond Chee, Manjeet Sandhu, Daniel Saitta, Elizabeth Chow, Lena Thin, Gareth J Walker, Gregory T Moore, Kate Lynch, Jane Andrews, Yoon K An, Robert V Bryant, Susan J Connor, Mayur Garg, Emily K Wright, Georgina Hold, Jonathan P Segal, Alex Boussioutas, Peter De Cruz, Mark G Ward, Miles P Sparrow

BMJ Open Jul 2024, 14 (7) e081787; DOI: 10.1136/bmjopen-2023-081787
Study protocol for a randomised, phase II, double-blind, experimental medicine study of obinutuzumab versus rituximab in ANCA-associated vasculitis: ObiVas
Dominic Paul McGovern, Mark E McClure, Matthew Coates, Simon Bond, Marcos Martinez Del Pero, Kim Mynard, Jacinta Lee, Rona M Smith, David R Jayne, Menna Ruth Clatworthy, Rachel B Jones

BMJ Open Jul 2024, 14 (7) e083277; DOI: 10.1136/bmjopen-2023-083277
Presentation of the first international research network to foster high-quality clinical trials testing non-pharmacological interventions (TRACTION network)
Ricardo J O Ferreira, Adriana Henriques, Rikke H Moe, Cristiano Matos, Anne-Therese Tveter, Nina Osteras, Paulo Nogueira, Andreia Silva Costa, Espen A Haavardsholm, Loreto Carmona, David Richards

BMJ Open Jul 2024, 14 (7) e081864; DOI: 10.1136/bmjopen-2023-081864

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