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BMJ Journals

clinical trials

Study protocol of a phase 2, dual-centre, randomised, controlled trial evaluating the effectiveness of probiotic and egg oral immunotherapy at inducing desensitisation or sustained unresponsiveness (remission) in participants with egg allergy compared with placebo (Probiotic Egg Allergen Oral Immunotherapy for Treatment of Egg Allergy: PEAT study)
Paxton Loke, Adriana Chebar Lozinsky, Francesca Orsini, Lydia Su-Yin Wong, Agnes Sze-Yin Leung, Elizabeth Huiwen Tham, Andreas L Lopata, Lynette Pei-Chi Shek, Mimi LK Tang

BMJ Open Jul 2021, 11 (7) e044331; DOI: 10.1136/bmjopen-2020-044331
Impact of duration of antibiotic prophylaxis on rates of surgical site infection (SSI) in patients undergoing mastectomy without immediate reconstruction, comparing a single prophylactic dose versus continued antibiotic prophylaxis postoperatively: a multicentre, double-blinded randomised control trial protocol
Abida K Sattar, Nida Zahid, Hania Shahzad, Rufina Soomro, Omema Saleem, Syed Faisal Mahmood

BMJ Open Jul 2021, 11 (7) e049572; DOI: 10.1136/bmjopen-2021-049572
Flash glucose monitoring with the FreeStyle Libre 2 compared with self-monitoring of blood glucose in suboptimally controlled type 1 diabetes: the FLASH-UK randomised controlled trial protocol
Emma G Wilmot, Mark Evans, Katharine Barnard-Kelly, M Burns, Iain Cranston, Rachel Ann Elliott, G Gkountouras, N Kanumilli, A Krishan, C Kotonya, S Lumley, P Narendran, Sankalpa Neupane, Gerry Rayman, Christopher Sutton, V P Taxiarchi, H Thabit, L Leelarathna

BMJ Open Jul 2021, 11 (7) e050713; DOI: 10.1136/bmjopen-2021-050713
Multicentre, randomised clinical trial comparing intravitreal aflibercept monotherapy versus aflibercept combined with reduced-fluence photodynamic therapy (RF-PDT) for the treatment of polypoidal choroidal vasculopathy
Chinmayi Himanshuroy Vyas, Chui Ming Gemmy Cheung, Colin Tan, Caroline Chee, Kelly Wong, Janice Marie N. Jordan-Yu, Tien Yin Wong, Anna Tan, Beau Fenner, Shaun Sim, Kelvin Yi Chong Teo

BMJ Open Jul 2021, 11 (7) e050252; DOI: 10.1136/bmjopen-2021-050252
Does app-based unguided self-management improve mental health literacy, patient empowerment and access to care for people with mental health impairments? Study protocol for a randomised controlled trial
André Kerber, Ina Beintner, Sebastian Burchert, Christine Knaevelsrud

BMJ Open Jul 2021, 11 (7) e049688; DOI: 10.1136/bmjopen-2021-049688
Clinical trial transparency and data sharing among biopharmaceutical companies and the role of company size, location and product type: a cross-sectional descriptive analysis
Sydney A Axson, Michelle M Mello, Deborah Lincow, Catherine Yang, Cary P Gross, Joseph S Ross, Jennifer Miller

BMJ Open Jul 2021, 11 (7) e053248; DOI: 10.1136/bmjopen-2021-053248
SYMPERHEART: an intervention to support symptom perception in persons with heart failure and their informal caregiver: a feasibility quasi-experimental study protocol
Gabrielle Cécile Santos, Maria Liljeroos, Roger Hullin, Kris Denhaerynck, Justine Wicht, Corrine Y Jurgens, Petra Schäfer-Keller

BMJ Open Jul 2021, 11 (7) e052208; DOI: 10.1136/bmjopen-2021-052208
Efficacy of a strategy-based intervention on text-level reading comprehension in persons with aphasia: a study protocol for a repeated measures study
Sarah-Maria Thumbeck, Philipp Schmid, Sophie Chesneau, Frank Domahs

BMJ Open Jul 2021, 11 (7) e048126; DOI: 10.1136/bmjopen-2020-048126
Prognostic factor analysis in patients with temporomandibular disorders after reversible treatment: study protocol for a prospective cohort study in China
Ling Zhang, Wentao Shi, Shenji Lu, Bin Cai, Shuai Fan, Yang Yang, Lili Xu

BMJ Open Jul 2021, 11 (7) e048011; DOI: 10.1136/bmjopen-2020-048011
Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson’s symptoms against other clinical monitoring methods: study protocol
Alejandro Rodríguez-Molinero, Jorge Hernández-Vara, Antonio Miñarro, Carlos Pérez-López, Àngels Bayes-Rusiñol, Juan Carlos Martínez-Castrillo, David A Pérez-Martínez

BMJ Open Jul 2021, 11 (7) e045272; DOI: 10.1136/bmjopen-2020-045272

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